Mosca is an unincorporated community and a U.S. Post Office in Alamosa County, Colorado, United States. It was named for the nearby Mosca Pass, which was named for the Spanish explorer, Luis de Moscoso Alvarado. The Mosca Post Office has the ZIP Code 81146.Mosca is located at 37°38′52″N 105°52′27″W / 37.64778°N 105.87417°W / 37.64778; -105.87417. The elevation of Mosca is 7,559 feet.